Tween 80

Polysorbate 80 (Tween 80) – Nonionic Emulsifier & Solubilizer for Cosmetic and Pharmaceutical Applications

Polysorbate 80, also known as Tween 80, is a nonionic surfactant and emulsifier widely used in cosmetic, pharmaceutical, food, and industrial formulations. It is primarily used to stabilize emulsions and improve the solubility of oils in water-based systems.

Due to its strong emulsifying properties and high compatibility with active ingredients, Polysorbate 80 is one of the most commonly used surfactants in skincare, injectable preparations, and liquid formulations.

Chemical & Technical Information

• Chemical Name: Polyoxyethylene (20) Sorbitan Monooleate

• Common Name: Polysorbate 80

• Other Name: Tween 80

• CAS Number: 9005-65-6

• Appearance: Viscous yellow to amber liquid

• Solubility: Soluble in water, alcohol, and vegetable oils

• HLB Value: ~15.0

• Type: Nonionic surfactant

Key Functions in Formulation

• Emulsifier

• Solubilizer

• Dispersing agent

• Stabilizer

• Wetting agent

Polysorbate 80 improves the stability of oil-in-water emulsions and helps prevent phase separation in creams, lotions, and liquid systems.

Applications of Polysorbate 80

Cosmetic & Personal Care Products

Polysorbate 80 is commonly used in:

• Creams and lotions

• Hair conditioners

• Makeup products

• Facial cleansers

• Bath oils

• Sunscreen formulations

It is especially effective for dispersing heavier oils compared to Polysorbate 20.

Pharmaceutical Applications

Polysorbate 80 is widely used in pharmaceutical manufacturing as:

• An emulsifier in topical creams and ointments

• A solubilizer in liquid medications

• A stabilizer in injectable and vaccine formulations

• A dispersing agent for active pharmaceutical ingredients

Its nonionic structure allows compatibility with a broad range of compounds.

Food & Industrial Applications

In regulated applications, Polysorbate 80 may be used as:

• A food-grade emulsifier

• A stabilizer in processed foods

• A dispersant in laboratory and biotech preparations

Polysorbate 80 vs. Polysorbate 20

While both are nonionic emulsifiers:

• Polysorbate 20 is better suited for lighter oils and fragrances.

• Polysorbate 80 is more effective for heavier oils and more complex emulsions.

This makes Polysorbate 80 a preferred choice for richer creams and pharmaceutical emulsions.

Storage & Handling

• Store in a cool, dry environment

• Keep tightly sealed

• Protect from direct sunlight and excessive heat

Polysorbate 80 remains an essential raw material in cosmetic and pharmaceutical manufacturing due to its emulsifying strength, formulation stability, and wide regulatory acceptance.